• We report herein an electrochemical analysis of the interact

  2022-04-02

  

  We report herein an electrochemical analysis of the interaction between L1 and sGC, where conventional solution phase voltammetry is combined with a novel technique, the voltammetry of microparticles (VMP), in order to obtain mechanistic information on the deactivation of sGC by L1. The VMP is a sol

• The role of the cyclic

  2022-04-02

  

  The role of the cyclic AMP regulated exchange factor Epac1 is emerging in cancer (Almahariq et al., 2015, Banerjee and Cheng, 2015, Parnell et al., 2015, Parnell et al., 2015, Schmidt et al., 2013). Interestingly, in cancer cell migration, activation of Epac1 can be linked to activation of Rac. As s

• Another possible effect of niacin is in altering immune cell

  2022-04-02

  

  Another possible effect of niacin is in altering immune cell trafficking; as it has been suggested that niacin therapy quells endothelial cell activation (Digby et al., 2010, Ganji et al., 2009) and thereby suppresses inflammatory cell recruitment (Wu et al. 2010). However, the impact of niacin on l

• Fig summarizes the underlying mechanism of SB on

  2022-04-02

  

  Fig. 7 summarizes the underlying mechanism of SB on inhibiting inflammation and maintaining epithelium barrier integrity in the TNBS-induced colitis model. Our findings not only explained the protective effect of SB on colon health, but also provided evidence that GPR109A likely constitutes a valid

• br Conclusion br Author contributions br Competing interests

  2022-04-02

  

  Conclusion Author contributions Competing interests Acknowledgments Introduction Reproductive performance is a major factor affecting profitability of dairy farms. The use of GnRH and prostaglandin F2α (PGF2α) in a coordinated fashion allows cows to be inseminated as a result of the u

• The occurrence of MDR in cancer patients undergoing

  2022-04-01

  

  The occurrence of MDR in cancer patients undergoing chemotherapy can be mimicked in the laboratory by culturing cancer Phentolamine Mesylate in the presence of chemotherapeutic drugs, thereby enforcing the evolution of acquired drug resistance. This has been described in multiple model systems inclu

• Previous studies have shown that zinc interacts

  2022-04-01

  

  Previous studies have shown that zinc interacts with other allosteric modulators at the glycine receptor (Kirson et al., 2013, McCracken et al., 2010, McCracken et al., 2013). Of note, the chelation of zinc via tricine decreases the effects of alcohol at α1-, α2-, and α3-containing glycine receptors

• Further explorations at the ortho and meta positions of

  2022-04-01

  

  Further explorations at the ortho- and meta-positions of the phenyl in the tail proceeded on the basis of the preliminary results. First, we investigated the fluorine group at the meta- (13p) and ortho-positions (13q) of the phenyl group, with both compounds being slightly less potent than 13o. Surp

• In vitro studies have shown that some antidepressant drugs b

  2022-04-01

  

  In vitro studies have shown that some antidepressant drugs bind to NMDA receptors and inhibit the binding of NMDA receptor ligands [18]. Similarly, several research teams have reported that tricyclic antidepressants can modulate the release and/or uptake of glutamate [19]. In this study, we found th

• SGLT inhibitors have been accepted as a

  2022-04-01

  

  SGLT-2 inhibitors have been accepted as a new class of antidiabetic agent (Kurosaki and Ogasawara, 2013). They limit renal glucose reabsorption and promote urinary excretion of glucose, thereby reducing plasma glucose levels (de Leeuw and de Boer, 2016, Jojima et al., 2016, Pérez López et al., 2010,

• br Materials and methods br

  2022-04-01

  

  Materials and methods Results Discussion In this study, we demonstrated, for the first time, that manipulation of AKR1D1 expression and activity is able to regulate glucocorticoid availability in liver and non-liver cell lines. AKR1D1 over-expression leads to increased glucocorticoid cleara

• br Phylogenetic analysis of vertebrate receptors for

  2022-04-01

  

  Phylogenetic analysis of vertebrate receptors for peptides similar to glucagon Genes for receptors for peptides similar to glucagon and other secretin-like hormones have been identified in a number of vertebrate species (Sivarajah et al., 2001, Chow et al., 2004, Irwin and Wong, 2005, Cardoso et

• Exo1 In the present study five

  2022-04-01

  

  In the present study, five Glu3-substituted analogues of GIP, namely (Ala3)GIP, (Lys3)GIP, (Phe3)GIP, (Trp3)GIP and (Tyr3)GIP, were synthesised and tested for DPP-IV resistance and biological activity both in vitro and in vivo. The properties of these analogues were compared with native GIP and (Pro

• The experiments indicate that a major component of

  2022-04-01

  

  The experiments indicate that a major component of the vasodilatation is due to antagonism of α 1-adrenoceptors. Evidence for α1-adrenoceptor antagonism is that vasodilatation was observed in Ifosfamide preconstricted with α1-adrenoceptor agonists, phenylephrine or methoxamine, but not in vessels pr

• In this study we demonstrate

  2022-04-01

  

  In this study, we demonstrate that the ETS transcription factor ETV5 is involved in the regulation of ghrelin system in response to the altered nutritional state. In the recent multiple GWAS studies, three single nucleotide polymorphisms (SNPs) of ETV5, rs7647305 (Thorleifsson et al., 2009; Willer

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