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Genome wide binding and transcriptome analyses demonstrate
2022-07-26
Genome-wide binding and transcriptome analyses demonstrate that Fbxl10 directly binds the Areg, Mdk, Lmnb1, Thbs1, Mgp and Cxcl12 locus and thereby might influences the expression of these migration associated genes. The expression of epidermal growth factor (EGF)-like molecule Amphiregulin (Areg)
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In the present study we investigated the mechanisms underlyi
2022-07-26
In the present study, we investigated the mechanisms underlying the ability of 5-FU to modify histone acetylation. Our results suggested that 5-FU induces global histone de-acetylation in CRC by promoting the degradation of p300 and CBP, two important homologous HATs catalyzing acetylation at multip
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xanthine oxidase inhibitors Mammals adapt to prolonged perio
2022-07-26
Mammals adapt to prolonged periods of food scarcity by releasing FFAs from adipose tissue and transforming them into energy-rich ketone bodies that are used as fuel by brain, muscle, and other organs (Kersten, 2014, Grabacka et al., 2016). Ketogenesis occurs primarily in hepatocytes, but its rate is
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Recently IL was also identified as an important mediator of
2022-07-26
Recently, IL-10 was also identified as an important mediator of collagen deposition in the development of HF [64,65]. It was shown, that this cytokine activates macrophages found in the hearts of mice suffering from diastolic dysfunction in the autocrine manner [64]. In response, specific subset of
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br Discussion br Conflict of interest br
2022-07-26
Discussion Conflict of interest Acknowledgements We thank Rosetta Barkley for expert technical assistance. We thank Robin Maser, James Calvet, Darren Wallace, and Jovanka Koo for many helpful discussions and expert technical advice. This work was supported by National Institutes of Health,
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NGS substitution linkage analysis and
2022-07-26
NGS substitution linkage analysis and haplotype reconstruction was previously only used for short genome segments and not in the context of antiviral resistance. We optimized this approach to cover a complete viral protein and major DAA target, enabling us to investigate resistance associated NS3P h
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Author contribution br Funding This work was supported by fu
2022-07-26
Author contribution Funding This work was supported by funding from St Vincent’s AMR. Hologic provided Panther equipment and Aptima HCV Quant Dx Viral Load assays. The sponsors had no rule in the analysis and interpretation of the study results, the manufacturer of reagents used in this study d
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In first wave first generation drugs
2022-07-26
In 2013, first-wave, first-generation drugs telaprevir and boceprevir was the first protease inhibitors (PIs) incorporated in Brazilian Clinical Guidelines for the treatment of patients infected with HCV ABT-263 1. Based on this 2013 Clinical Guideline, telaprevir could be used for both naïve and e
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In contrast to sGC stimulators sGC
2022-07-26
In contrast to sGC stimulators, sGC activators promote enzymatic activity of sGC containing oxidized heme iron (Fe3+) or missing the heme group. A-350619 is one of the oldest activators of sGC to be discovered. A-350619 increased sGC activation in a non-additive manner with respect to YC-1, leading
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Decreasing GSK activity has therapeutic benefits
2022-07-26
Decreasing GSK-3β activity has therapeutic benefits in animal model of colitis [45] and traumatic 1423 injury [46] and ischemia/reperfusion injury [47,48]. In brain, activation of GSK-3β promotes Aβ toxicity by elevating APP expression and its amyloidogenic cleavage, and by dysregulating Aβ clearan
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It has been proposed that HCA
2022-07-26
It has been proposed that HCA1 may be a better target than HCA2 to treat dyslipidemia and to prevent progression of atherosclerosis, because HCA1 is less widely expressed, and HCA1 activation does not result in flushing. However, since the antilipolytic effects mediated by HCA2 appear to be not the
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br Conclusions Beta cell specific
2022-07-26
Conclusions Beta cell-specific expression in human islets of DGCR2, GBF1, GPR44 and SerpinB10 has not previously been described, although the proteins have partly been characterized in other contexts not related to beta cgrp or diabetes. DGCR2, GPR44 and SerpinB10 were negative in all other cell
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In the present study administration of
2022-07-26
In the present study, administration of both muscimol and bicuculline also affected the biosynthesis of GnRHR. A significant decrease in GnRHR level in the POA, AH, VMH and SME following muscimol treatment as well as the opposite effect induced by bicuculline indicates that GnRHR gene expression is,
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In parallel we were also preparing
2022-07-26
In parallel, we were also preparing and evaluating other piperidine bioisosteres and modifications to – to further access additional novel intellectual property (IP) space. Modeling work suggested that 4-position homologated piperidines, as well as 3-position homologated azetidines overlapped favora
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AFB Fapy dG has been long recognized as a
2022-07-26
AFB1-Fapy-dG has been long recognized as a substrate for nucleotide excision repair [24,25]. However, we recently demonstrated that this lesion is removed by Flavopiridol hydrochloride excision repair. We showed that DNA glycosylase NEIL1, a member of the Fpg/Nei glycosylase family, could excise AFB
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