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The R pycnus arginase was identical to
2023-04-10
The R. pycnus arginase was 65% identical to the published B. caldovelox arginase sequence (AAB06939). Furthermore, the R. pycnus arginase gene was 62%, 45%, 36% and 22% identical to the published arginase sequences from Bacillus thuringiensis (AJI37018), Thermus thermophiles (WP_038039155), Human ar
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Therefore a number of homoisoflavonoids may be designed in f
2023-04-10
Therefore, a number of homoisoflavonoids may be designed in future that may be effective against angiogenesis for treating ocular neovascularization. As this Demethoxycurcumin synthesis current study deals with robust molecular modeling techniques on SH-11037 (cpd 15) and related homoisoflavonoids
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and LO are members of the lipoxygenase family
2023-04-10
5- and 12/15-LO are members of the lipoxygenase family that convert arachidonic Tosedostat into lipid mediators such as leukotriene B4 (LTB) and 12()-hydroxyeicosatetraenoic acid (HETE) and 15()-HETE, respectively. Evidence from several in vitro and in vivo studies has shown that activation of the
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Adiponectin is an adipokine whose circulating
2023-04-07
Adiponectin is an adipokine whose circulating level is depleted in a number of metabolic diseases including insulin resistance, diabetes and cancer (Khan et al., 2015, Singh et al., 2014a, Singh et al., 2014b, Yamauchi et al., 2014). Despite its importance in health and pathophysiology, adiponectin
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br Materials and methods br Results br Discussion More
2023-04-07
Materials and methods Results Discussion More experiments were performed in order to explain the mechanism that is involved in psora receptor death both PC3 and Hep G2 cells using compound 5. Results showed that this compound inhibits cell viability inducing apoptosis in a concentration-de
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Epithelial mesenchymal transition EMT is
2023-04-07
Epithelial-mesenchymal transition (EMT) is the process by which epithelial cells are trans-differentiated into motile mesenchymal cells. During EMT, epithelial cells reorganize their cortical DCG IV synthesis cytoskeleton, lose their junctions and apical-basal polarity, change cell shape, and repro
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Search sphere This sphere includes the acetylcholine
2023-04-07
Search sphere 1: This sphere includes the o-Phenanthroline synthesis binding site between the α–γ subunits. The center point of the search area was located at x=35.26, y=77.67, z=137.74 and the initial search radius was set to 27Å which assures that the corresponding area outside the channel pore of
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Fig A shows a schematic
2023-04-07
Fig. 2A shows a schematic representation of histological results according to the Franklin and Paxinos Mouse Brain Atlas (2001). The black circles represent the sites of drug infusion that were on-target within the amygdala. Gray circles represent the animals that had infusion locations outside the
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Many reports have well documented that
2023-04-07
Many reports have well documented that signaling pathways play a pivotal role in controlling longevity. The most studied of these pathways is the IGF-1 pathway [11,12]. A disruption of this pathway has been found to extend longevity in different groups of species starting from Caenorhabditis elegans
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br Regulation of V ATPase assembly
2023-04-07
Regulation of V-ATPase assembly in response to changes in amino MOG (35-55) levels A central regulator of cell growth and metabolism is mTORC1 [38]. mTORC1 integrates signals from nutrient availability and growth factor receptors to control such processes as protein and lipid synthesis and autop
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Exposure to cisplatin with ATR inhibitor resulted in
2023-04-06
Exposure to cisplatin with ATR inhibitor resulted in an increase in cisplatin-DNA adducts, especially in cells with ATM deficiency. This finding indicates that suppressing ATR-Chk1 signaling with VE-822 enhances cisplatin activity by enabling the drug to form DNA adducts. Therefore, VE-822 may incre
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The previous reports studied only the apoptosis process in a
2023-04-06
The previous reports studied only the apoptosis process in a single cell. In our case we generalized these models inspired by the results of Albeck et al. (2008) and Raychaudhuri et al. (2008), to study the apoptosis cell death after photodynamic therapy in those areas of the tumor that are not expo
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Consistent with the above prediction there are additional
2023-04-06
Consistent with the above prediction, there are additional reports in which HMGA proteins have been demonstrated to facilitate recruitment of chromatin remodeling complexes to gene regulatory regions containing positioned nucleosomes during the transcriptional activation process. One particularly il
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br Identification of the croaker mAR
2023-04-06
Identification of the croaker mAR cDNA Testosterone (T) was observed to alter steroidogenesis through a nongenomic mechanism (not blocked by the transcription inhibitor, actinomycin D) in Atlantic croaker ovarian tissues (Braun and Thomas, 2003). This action of T was mimicked by T conjugated to B
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Consideration of the rate of product formation
2023-04-06
Consideration of the rate of product formation at different substrate concentrations and estimation of Michaelis-Menten parameters gives some insight into the possible mechanisms underlying the observed decreases in enzyme activity. Estimates based on two-substrate concentrations lack precision and
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