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br Future view and implications The selection
2024-03-12
Future view and implications The selection and spread of multi(drug)-resistant microorganisms over the last decades has become a major and global public health concern [35]. Two growing threats originating from the fungal kingdom, i.e. Aspergillus fumigatus and Candida auris[36], [37], re-emphasi
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The first identified auxiliary subunit stargazin is essentia
2024-03-12
The first identified auxiliary subunit, stargazin, is essential for AMPAR function in cerebellar granule neurons (Hashimoto et al., 1999). Subsequently, a family of six transmembrane AMPAR regulatory proteins (TARPs) were defined that modify channel trafficking, gating, and pharmacology (Kato and Br
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Analysis of the crystal structures of LAPs from E coli
2024-03-12
Analysis of the crystal structures of LAPs from E. coli[29], bovine eye lens [30], Pseudomonas putida[27], tomato [31] and P. falciparum[32] revealed that the monomer of M17-family LAP is composed of two domains: the smaller, variable N-terminal domain and the larger, conserved C-terminal domain tha
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Introduction Lipoxygenases LOXs are key enzymes that catalyz
2024-03-12
Introduction Lipoxygenases (LOXs) are key enzymes that catalyze the polyunsaturated fatty acids (PUFAs) such as arachidic CM-272 receptor (AA), linoleic acid (LA) and others unsaturated fatty acids (Brash, 1999). LOXs are expressed in immune, neural, epithelial, tumor cells and other cells (Claess
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Another possible scenario is that the same pathologic proces
2024-03-12
Another possible scenario is that the same pathologic process has different effects in different people. It might be that the pathway outlined in Fig. 6A is operative in some individuals, but other individuals have a factor Q (which could be genetic or environmental) that blocks the effect of A on T
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As one of emerging high throughout methods metabolomics dete
2024-03-12
As one of emerging high-throughout methods, metabolomics detects metabolites which are ultimate response of biological systems to environmental changes [14]. Metabolomics uncovers metabolic alteration at the systems level. Comparison of global metabolic profiling reflects some unidentified biologica
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The importance of insulin in controlling lipolysis and fat
2024-03-11
The importance of insulin in controlling lipolysis and fat mass is further emphasized by mouse models with alterations in the insulin signaling pathway of adipocytes. For example, mice with a tamoxifen-inducible knockout of the insulin receptor in mature adipocytes reveal a substantial decrease of a
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We have previously shown that the antinociceptive effect of
2024-03-11
We have previously shown that the antinociceptive effect of tramadol, an analgesic that, like paracetamol is able to increase serotonin levels within CNS, is potentiated or antagonized respectively by a 5-HT1A/B nonspecific Biotin-azide blockade or activation (Rojas-Corrales et al., 2000). Moreover,
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Small RhoGTPases are single domain nucleotide
2024-03-11
Small RhoGTPases are single-domain nucleotide-dependent binary switches that act as highly-tuned regulators in signal transduction [1]. The cycling between active GTP-bound and inactive GDP-bound forms allows RhoGTPases to bind to or to dissociate from downstream effectors, respectively [2]. Guanine
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br Introduction ACK or Activated Cdc Associated
2024-03-11
Introduction ACK1, or Activated Cdc42-Associated Kinase, located on chromosome 3q, is a ubiquitously expressed non-receptor tyrosine kinase cloned from a human dapt medical abbreviation cDNA library (Manser et al., 1993). It was first identified to bind to activated Cdc42, a small Ras GTPase via
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Further evidence for ACh GABA cotransmission had also been o
2024-03-11
Further evidence for ACh/GABA cotransmission had also been observed in the cortex. Extensive axonal arborization from cholinergic BF neurons exists throughout the cortical layers, allowing direct observation of cholinergic synaptic terminals. One study in the visual cortex of cat examined immunolabe
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Mistletoe is universal name for various species
2024-03-11
Mistletoe is universal name for various species of parasitic plant which grows attached to and within the branches of host trees such as apple, elm, oak and pine. Mistletoe extract prepared from Viscum album, a species of mistletoe in the family Santalaceae, is generally known as European mistletoe
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95 9 br Acknowledgements This work was supported by the FedE
2024-03-11
Acknowledgements This work was supported by the FedEx Institute of Technology at The University of Memphis (to DLB and ALP), NSF REU CHE 1156738 (to ALP in support of RSS), and NIHCA921060 (to GT). This material is based upon work supported by the National Science Foundation under Grant No. CHE-1
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ABC super family proteins are found in all forms
2024-03-11
ABC super family proteins are found in all forms of life and ABC-F subfamily of proteins are involved in cellular processes such as translational control and antibiotic resistance by ribosomal protection [3], [5]. The Mtb ABC proteins that do not contain transmembrane domains have not been studied [
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The canonical binding sites to which or contribute are
2024-03-11
The canonical Riluzole to which α2, α3, or α5 contribute are highly similar. Therefore, differences in ligand affinity will not be large even if a ligand makes optimal use of the small differences in the pockets. As a possible alternative approach to achieve separation of compound effects, ligands
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