• Regarding androgens it is known that they are also essential

  2024-10-16

  

  Regarding androgens, it is known that they are also essential for reproductive success (Walters et al., 2010). At the molecular level, their effects are produced mainly by dihydrotestosterone (DHT), arising from the conversion of testosterone by the enzyme 3-oxo-5-alpha-steroid-4-dehydrogenase (enco

• ubiquitin e3 ligase Whereas more research is needed to

  2024-10-16

  

  Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the ubiquitin e3 ligase that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN completely reversed

• The SKOV and SKOV TR cells were exposed to stepwise

  2024-10-16

  

  The SKOV3 and SKOV3TR lipoxygenase inhibitor were exposed to stepwise increased concentration of paclitaxel with or without a different concentration of autophagy inhibitor (3-MA or HCQ) to further evaluate whether suppression of autophagy affected the growth and drug sensitivity of ovarian cancer

• br Role of autophagy in

  2024-10-16

  

  Role of autophagy in alcoholic cardiomyopathy Concluding remarks The genetic and phenotypic heterogeneity in alcoholic cardiac injury has been recognized despite the seemingly beneficial effects of low to moderate alcohol consumption [8]. Although oxidative stress is well established in the pa

• br Aurora A Aurora B and Aurora C small

  2024-10-16

  

  Aurora-A, Aurora-B and Aurora-C small molecule inhibitors Nicholas et al. described phenotypic cellular screening of new highly potent and selective class of Aurora kinase inhibitors. Fragment based approach was utilized; core structure of 57 (Fig. 5) was optimized and selective inhibitor 58 (Fig

• netilmicin In plants altered expression of Aurora kinases re

  2024-10-16

  

  In plants, altered expression of Aurora kinases results in impaired meiotic divisions followed by the formation of aneuploid or polyploid progenies [21]. This observation is interesting from an evolutionary point of view because it can be assumed that, during evolution, the influence of biotic and a

• Recent studies have demonstrated significant cross talk betw

  2024-10-16

  

  Recent studies have demonstrated significant cross-talk between XRCC1 (a key player in AdipoRon excision repair (BER) and single strand break repair) and DDR [30], [31], [32]. ATM and DNA-PKcs are known to be involved in the phosphorylation of XRCC1 to promote BER [30], [31]. We have recently shown

• br Materials and methods br Results

  2024-10-16

  

  Materials and methods Results and discussion During recent years, recombinant ASK1 has been obtained by expensive baculovirus-insect cell Carbidopa systems [20], [27]. In the present study, we constructed recombinant ASK1 and expressed in active form at high level in E. coli. Human ASK1 cata

• Additional support for a role of HMGN in enhancing

  2024-10-16

  

  Additional support for a role of HMGN1 in enhancing DNA repair comes from studies of transcription-coupled repair (TCR) in human cells. Lesions in the template strand of DNA induced by UV light stall the movement of RNA polymerase II (RNAPII) and interrupt transcription. Removal of these transcripti

• br Duality of interest br Contribution

  2024-10-15

  

  Duality of interest Contribution statement Acknowledgments Introduction Rapid, cell surface-initiated steroid actions have been reported for all major groups of steroid hormones and our understanding of membrane-mediated steroid actions has progressed rapidly over the last two decades. M

• enolase br Glioblastoma GBM is the highest grade glioma

  2024-10-15

  

  Glioblastoma GBM is the highest-grade glioma (Grade IV) according to WHO classification and belongs to the most malignant form of enolase tumor. It is an incurable disease despite the use of aggressive treatments that include surgery and radiotherapy, usually in combination with chemotherapy [13

• Our studies suggest that AdipoR and AdipoR genes are

  2024-10-15

  

  Our studies suggest that AdipoR1 and AdipoR2 genes are expressed in multiple tissues in the chicken wherein both receptors are likely to mediate the physiological effects of adiponectin. We determined the relative expression of AdipoR1 and AdipoR2 mRNA in various tissues and found that skeletal musc

• Our previous work fails to show

  2024-10-15

  

  Our previous work fails to show any maternal effect with blockade of 5-HT2A receptor, as acute and repeated treatment of MDL100907 does not alter maternal behavior at the behaviorally active doses (Chen et al., 2014). In the present study, MDL100907 pretreatment attenuated the maternal disruptive ef

• dynorphin br Conclusion Our study of late life

  2024-10-15

  

  Conclusion Our study of late-life depression provides evidence of genotype-specific associations between depression and ACE methylation, as well as inverse correlations between ACE methylation and dynorphin secretion. These findings highlight the potential need to consider methylation levels in c

• br Funding br Introduction The interest in the effects

  2024-10-15

  

  Funding Introduction The interest in the effects of endocrine disrupting chemicals (EDCs) in the aquatic environment continues to increase over the past decade, specifically those that act on steroidogenic pathways. EDCs that include synthetic androgenic and estrogenic compounds can severely a

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