• br Significance Dysregulation of dopamine

  2020-10-21

  

  Significance Dysregulation of dopamine homeostasis contributes to Parkinson\'s disease (PD). The nuclear receptor Nurr1 plays a central role in dopamine homeostasis, regulating the transcription of salubrinal receptor governing the synthesis, packaging, and reuptake of dopamine. Efforts to capita

• Common enzyme quantitative methods include enzyme

  2020-10-21

  

  Common enzyme quantitative methods include enzyme-linked immunosorbent assay [,] (ELISA), chemiluminescence (CLIA) [, , ] and immunochromatography []. The advantages of ELISA are cost reduction and automation, but non-specific reaction caused by HOOK effect, false positive caused by cross-contaminat

• QSAR based on the D

  2020-10-21

  

  QSAR based on the 3D structures of ligands plays an important role in the ligand-based drug discovery and design [12]. Comparative molecular field analysis, CoMFA [11], and comparative molecular similarity index analysis, CoMSIA [12] are among the most popular QSAR models. They focus on changes in 3

• nitric oxide inhibitor The aniline R group was extensively e

  2020-10-21

  

  The aniline R2 group was extensively explored and a large variety of substitution was tolerated at several positions on the aryl ring (). Notably, substitution at the 3-position often gave increased potency. Increasing lipophilic bulk at this position gave increasing potency within an ether series (

• Previously published results on this topic are inconsistent

  2020-10-21

  

  Previously published results on this topic are inconsistent. Stressin1-A, a novel CRF1 receptor agonist, increased anxiety-like behavior in the social interaction and shock-probe tests [51]. Pharmacological blockade of CRF1 (NBI-30775) reversed both CRF-induced increases in startle and CRF-induced d

• br Experimental section br Results br Discussion In our

  2020-10-21

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised (+)- Corydaline mg did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a pa

• Cryoprotectant equilibration and the response to ice concent

  2020-10-21

  

  Cryoprotectant equilibration and the response to ice concentrated media are the two facets of cellular cryobiological protocols most commonly covered by mathematical modeling. In these models, cotransport are typically assumed to have uniform, spatially independent extracellular concentrations and t

• Many studies have also demonstrated that

  2020-10-21

  

  Many studies have also demonstrated that CK2 inhibition profoundly affects the PI3K/AKT pathway in different cancer models; promising results have been obtained in hematological malignancies (Buontempo et al., 2014, Borgo et al., 2013, Piazza et al., 2012, Cheong et al., 2010, Gowda et al., 2016), a

• The oxidation of the lipid fraction of

  2020-10-21

  

  The oxidation of the lipid fraction of meat is an extremely complex process because of the high sensitivity of oxidation products to decomposition, their reactions with other components, the complex effect of catalysts and the presence of antioxidants. These changes are the main cause of limited she

• Adapalene Kshirsagar et al previously reported an associatio

  2020-10-21

  

  Kshirsagar et al. previously reported an association between CHK2thr68 expression and the presence of the chromatin remodeling factor Rsf-1 in solid HGSC specimens [22]. Rsf-1 expression was previously analyzed in our effusion series and was found to be related to poor survival [23]. Analysis of the

• br Criteria for ER targeted

  2020-10-21

  

  Criteria for ER-targeted fluorescent probes Survey of fluorescent probes Proposed approach to high affinity fluorescent steroidal ER probes Our proposed approach to the development of a new generation of fluorescent estrogen receptor imaging agents employs many of the elements present in th

• Altered brain insulin signaling and CNS

  2020-10-21

  

  Altered GSK J4 insulin signaling and CNS hypometabolism are also associated with pathogenesis of neurodegeneration. Insulin receptors are mostly located in the cerebral cortex, hippocampus, cerebellum, hypothalamus and olfactory bulb, possess an effective role in the regulation of central glucose m

• It is known that cigarette smoke increases the oxidative

  2020-10-20

  

  It is known that cigarette smoke increases the oxidative burden in the lungs of mice with emphysema, which leads to oxidative stress [[34], [35], [36]]. However, in addition to cigarette smoke, studies have shown that endogenous oxidative stress is associated with proteolytic KX2-391 synthesis in s

• br DUBs in regulation of critical

  2020-10-20

  

  DUBs in regulation of critical steps in tumor metastasis Tumor metastasis comprises a complicated series of biological processes in terms of the invasion-metastasis cascade that requires cancer Dihydroeponemycin synthesis to (1) migrate and invade from the origin sites through the extracellular

• In order to derive a better understanding of the results

  2020-10-20

  

  In order to derive a better understanding of the results from our SAR study, we utilized Glide to model the binding of the SAR compounds with the non-active site pocket of TS-DHFR shown in C. The majority of models position the phenolic moiety of these compounds within the non-active site pocket, wh

14584 records 770/973 page Previous Next First page 上5页 766767768769770 下5页 Last page